Structural changes induced by interactions between thyroid hormones and phospholipid membranes: a Raman Spectroscopy study
Previous reports from our laboratory have shown that thyroid hormones induce changes in the fluidity and permeability of phospholipid bilayers and modify the transmembrane dipolar organization according to their iodine content. The interactions of T2, T3, and T4 with a model membrane of dilauroylpho...
| Autores: | , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2012 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/21993 |
| Acceso en línea: | http://hdl.handle.net/11336/21993 |
| Access Level: | acceso abierto |
| Palabra clave: | Thyroid Hormones Phospholipids Vibrational Analysis Confocal Raman Microscopy https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| Sumario: | Previous reports from our laboratory have shown that thyroid hormones induce changes in the fluidity and permeability of phospholipid bilayers and modify the transmembrane dipolar organization according to their iodine content. The interactions of T2, T3, and T4 with a model membrane of dilauroylphosphatidylcholine in the liquid-crystalline phase were analyzed by confocal Raman spectroscopy. Insights into the nature of the hormone effects on the membrane properties, as well as the structural adaptations of the hormones in response to the lipid environment were derived from the spectral changes. The series of progressive iodine substituents on the ring-β allowed us to correlate the hormone effects according to the number and the orientation of the iodine atoms. T4 was responsible for producing the highest alteration in the hydrophobic region of the membrane. |
|---|