Inhibition of galectins in cancer: Biological challenges for their clinical application
Galectins play relevant roles in tumor development, progression and metastasis. Accordingly, galectins are certainly enticing targets for medical intervention in cancer. To date, however, clinical trials based on galectin inhibitors reported inconclusive results. This review summarizes the galectin...
| Autores: | , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/219134 |
| Acceso en línea: | http://hdl.handle.net/11336/219134 |
| Access Level: | acceso abierto |
| Palabra clave: | CANCER TREATMENTS GALECTIN INHIBITORS GALECTINS MEDICAL INTERVENTION FOR CANCER TUMOR MICROENVIRONMENT https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| Sumario: | Galectins play relevant roles in tumor development, progression and metastasis. Accordingly, galectins are certainly enticing targets for medical intervention in cancer. To date, however, clinical trials based on galectin inhibitors reported inconclusive results. This review summarizes the galectin inhibitors currently being evaluated and discusses some of the biological challenges that need to be addressed to improve these strategies for the benefit of cancer patients. |
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