Iridium oxide (IV) nanoparticle-based lateral flow immunoassay

Lateral flow biosensors are paper-based devices that allow the detection of different types of analytes with quickness, robustness and selectivity, without leaving behind paper sensors benefits as low-cost, recyclability and sustainability. Nanomaterials have been widely reported in lateral flow bio...

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Detalles Bibliográficos
Autores: Quesada-González, Daniel, Sena-Torralba, Amadeo, Prio Wicaksono, Wiyogo, Escosura-Muñiz, Alfredo de la, Ivandini, Tribidasari A., Merkoçi, Arben
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/200625
Acceso en línea:http://hdl.handle.net/10261/200625
Access Level:acceso abierto
Palabra clave:Iridium oxide nanoparticles
Lateral flow immunoassay
Paper-based biosensor
Mobile phone sensing
Descripción
Sumario:Lateral flow biosensors are paper-based devices that allow the detection of different types of analytes with quickness, robustness and selectivity, without leaving behind paper sensors benefits as low-cost, recyclability and sustainability. Nanomaterials have been widely reported in lateral flow biosensors, offering new sensing strategies based on optical or electrical detection techniques. Looking for other advantageous nanomaterials, we propose for the first time the use of iridium oxide (IV) nanoparticles in lateral flow assays for the detection of human immunoglobulin as a model protein. These nanoparticles can be easily prepared and conjugated with biomarkers. Their dark blue color gives a high contrast against the white background of the strips being in this way excellent labels.