Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry

ObjectivesTo compare mortality rates between GCA patients and the general population in Spain, and to identify associated factors influencing mortality. MethodsARTESER, a multicenter registry by the Spanish Society of Rheumatology, includes GCA patients from June 2013 to March 2019. Demographic, cli...

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Detalles Bibliográficos
Autores: Molina Collada, Juan, Domínguez Álvaro, Marta, Melero González, Rafael B., Miguel, Eugenio de, Silva Díaz, Maite, Valero Jaimes, Jesús Alejandro, González, Ismael, Sánchez Martín, Julio, Narváez García, Francisco Javier, Calvet, Joan, Casafont Solé, Ivette, Huaylla, Anderson, Galíndez Agirregoikoa, Eva, Calvo Zorrilla, Itziar, Lluch, Judit, Belzunegui, Joaquín María, López Domínguez, Luis, Egues Dubuc, Cesar Antonio, Silva Fernández, Lucia, Román Ivorra, Jose A, Labrada Arrabal, Selene, Vasques Rocha, Margarida, Iñiguez, Carlota L., Bustabad Reyes, María Sagrario, Campos Fernández, Cristina, Alcalde Villar, María, Mas, Antonio Juan, Blanco, Ricardo, Arteser Project Collaborative Group
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/219395
Acceso en línea:https://hdl.handle.net/2445/219395
Access Level:acceso abierto
Palabra clave:Mortalitat
Supervivència
Vasculitis
Arteritis de cèl·lules gegants
Mortality
Survival
Giant cell arteritis
Descripción
Sumario:ObjectivesTo compare mortality rates between GCA patients and the general population in Spain, and to identify associated factors influencing mortality. MethodsARTESER, a multicenter registry by the Spanish Society of Rheumatology, includes GCA patients from June 2013 to March 2019. Demographic, clinical, imaging, histological and mortality data were collected retrospectively. Only patients with at least one year of follow-up were included for analysis. The mortality rates were expressed as the number of deaths per 1000 person-years, with 95% confidence interval (CI) by sex and age group. Kaplan-Meier method was performed for survival analysis. The factors influencing mortality were analyzed using Cox regression model. ResultsA total of 1200 patients with GCA were analyzed, with a mean (SD) follow-up of 2.18 (1.53) years. The overall five-year cumulative mortality rate (95%CI) was 37.86 (31.75-43.96) per 1000 patients/year. The cumulative mortality rate was significantly higher in males than females (59.04vs29.06; p<0.001). The age- and sex-adjusted cumulative mortality rate was similar to the Spanish general population (19.75vs20.72;p=0.559). In the multivariate analysis, older age (HR 1.11, 95%CI 1.073-1.142) and male sex (HR 1.775, 95%CI 1.214-2.594) were associated with increased mortality. Headache (HR 0.55, 95%CI 0.362-0.843) and high hemoglobin levels (HR 0.85, 95%CI 0.744-0.970) were protective factors against death. ConclusionsThe overall five-year age- and sex-adjusted cumulative mortality rate in GCA is similar compared to the general population. Older age and male sex appear to be associated with an increased risk of mortality, whereas headache and high hemoglobin levels might serve as protective factors against death.

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