Coating typologies and constrained swelling of hyaluronic acid gels within scaffold pores
[EN] A set of elastomeric scaffolds with a well defined porous structure was prepared with a template leaching procedure and coated with hyaluronic acid solutions. Depending on the coating process parameters the hyaluronic acid deposited on the pores had configurations ranging from thin disconnected...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2011 |
| País: | España |
| Institución: | Universitat Politècnica de València (UPV) |
| Repositorio: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| Idioma: | inglés |
| OAI Identifier: | oai:riunet.upv.es:10251/100811 |
| Acceso en línea: | https://riunet.upv.es/handle/10251/100811 |
| Access Level: | acceso abierto |
| Palabra clave: | Hyaluronic acid/hyaluronan Scaffold Swelling Coating layer Coating process parameter Continuous layers Elastomeric scaffolds Equilibrium swelling Gel swelling Hyaluronic acid coatings Hyaluronic acids Leaching procedures Pore surface Porosity changes Porous structures Standard theories Swelling capacities Agglomeration Coatings Gels Leaching Organic acids Scaffolds Scaffolds (biology) Scanning electron microscopy Tissue Water vapor Acrylic acid derivative Elastomer hyaluronic acid Molecular scaffold poly(ethyl acrylate) Unclassified drug Adsorption Article Chemical structure Controlled study Elasticity Gel Heart Humidity Material coating Porosity Priority journal Surface property Coated Materials, Biocompatible Tissue Scaffolds Water TERMODINAMICA APLICADA (UPV) MAQUINAS Y MOTORES TERMICOS |
| Sumario: | [EN] A set of elastomeric scaffolds with a well defined porous structure was prepared with a template leaching procedure and coated with hyaluronic acid solutions. Depending on the coating process parameters the hyaluronic acid deposited on the pores had configurations ranging from thin disconnected aggregates to a thick continuous layer on the pore surface. The development of the coating layer was studied by scanning electron microscopy and the materials were subjected to dynamical and equilibrium swelling experiments in a water vapor ambient of fixed activity. The porosity change due to coating and to swelling of the coating layer were determined. The hyaluronic acid coating the pores has a different swelling capacity depending on the type of layer formed, as a consequence of the scaffold constraint and of the layer typology. These factors were investigated analytically by modifying the standard theory of gel swelling. An experimental quantity is introduced which reflects the constrainment build-up on gel swelling. © 2011 Elsevier Inc. |
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