Self-administered transcranial direct current stimulation treatment of knee osteoarthritis alters pain-related fNIRS connectivity networks

Epub 2023 Mar 31

Detalles Bibliográficos
Autores: Montero-Hernandez, Samuel, Pollonini, Luca, Park, Lindsey, Martorella, Geraldine, Miao, Hongyu, Mathis, Kenneth B., Ahn, Hyochol
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/60826
Acceso en línea:http://hdl.handle.net/10810/60826
Access Level:acceso abierto
Palabra clave:transcranial direct current stimulation
functional connectivity
pain
knee osteoarthritis
neuromodulation
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spelling Self-administered transcranial direct current stimulation treatment of knee osteoarthritis alters pain-related fNIRS connectivity networksMontero-Hernandez, SamuelPollonini, LucaPark, LindseyMartorella, GeraldineMiao, HongyuMathis, Kenneth B.Ahn, Hyocholtranscranial direct current stimulationfunctional connectivitypainknee osteoarthritisneuromodulationEpub 2023 Mar 31Significance: Knee osteoarthritis (OA) is a disease that causes chronic pain in the elderly population. Currently, OA is mainly treated pharmacologically with analgesics, although research has shown that neuromodulation via transcranial direct current stimulation (tDCS) may be beneficial in reducing pain in clinical settings. However, no studies have reported the effects of home-based self-administered tDCS on functional brain networks in older adults with knee OA. Aim: We used functional near-infrared spectroscopy (fNIRS) to investigate the functional connectivity effects of tDCS on underlying pain processing mechanisms at the central nervous level in older adults with knee OA. Approach: Pain-related brain connectivity networks were extracted using fNIRS at baseline and for three consecutive weeks of treatment from 120 subjects randomly assigned to two groups undergoing active tDCS and sham tDCS. Results: Our results showed that the tDCS intervention significantly modulated pain-related connectivity correlation only in the group receiving active treatment. We also found that only the active treatment group showed a significantly reduced number and strength of functional connections evoked during nociception in the prefrontal cortex, primary motor (M1), and primary somatosensory (S1) cortices. To our knowledge, this is the first study in which the effect of tDCS on pain-related connectivity networks is investigated using fNIRS. Conclusions: fNIRS-based functional connectivity can be effectively used to investigate neural circuits of pain at the cortical level in association with nonpharmacological, self-administered tDCS treatment.S.M.H. and L.P. would like to acknowledge the support of the National Science Foundation (Grant Nos. CNS 1650536 and 2137255) and I/UCRC for Building Reliable Advances and Innovation in Neurotechnology. LP also acknowledges the U.S. Fulbright Scholar Program and the Fulbright Spain Commission for sponsoring his stay at the Basque Center on Cognition, Brain and Language. The research reported in this publication was supported by the National Institute of Nursing Research of the National Institutes of Health (Award No. R15NR018050).SPIE.DIGITAL LIBRARY202320232023info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/60826reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://www.spiedigitallibrary.org/journals/neurophotonicsinfo:eu-repo/semantics/openAccess© The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License.oai:addi.ehu.eus:10810/608262026-06-18T09:23:17Z
dc.title.none.fl_str_mv Self-administered transcranial direct current stimulation treatment of knee osteoarthritis alters pain-related fNIRS connectivity networks
title Self-administered transcranial direct current stimulation treatment of knee osteoarthritis alters pain-related fNIRS connectivity networks
spellingShingle Self-administered transcranial direct current stimulation treatment of knee osteoarthritis alters pain-related fNIRS connectivity networks
Montero-Hernandez, Samuel
transcranial direct current stimulation
functional connectivity
pain
knee osteoarthritis
neuromodulation
title_short Self-administered transcranial direct current stimulation treatment of knee osteoarthritis alters pain-related fNIRS connectivity networks
title_full Self-administered transcranial direct current stimulation treatment of knee osteoarthritis alters pain-related fNIRS connectivity networks
title_fullStr Self-administered transcranial direct current stimulation treatment of knee osteoarthritis alters pain-related fNIRS connectivity networks
title_full_unstemmed Self-administered transcranial direct current stimulation treatment of knee osteoarthritis alters pain-related fNIRS connectivity networks
title_sort Self-administered transcranial direct current stimulation treatment of knee osteoarthritis alters pain-related fNIRS connectivity networks
dc.creator.none.fl_str_mv Montero-Hernandez, Samuel
Pollonini, Luca
Park, Lindsey
Martorella, Geraldine
Miao, Hongyu
Mathis, Kenneth B.
Ahn, Hyochol
author Montero-Hernandez, Samuel
author_facet Montero-Hernandez, Samuel
Pollonini, Luca
Park, Lindsey
Martorella, Geraldine
Miao, Hongyu
Mathis, Kenneth B.
Ahn, Hyochol
author_role author
author2 Pollonini, Luca
Park, Lindsey
Martorella, Geraldine
Miao, Hongyu
Mathis, Kenneth B.
Ahn, Hyochol
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv transcranial direct current stimulation
functional connectivity
pain
knee osteoarthritis
neuromodulation
topic transcranial direct current stimulation
functional connectivity
pain
knee osteoarthritis
neuromodulation
description Epub 2023 Mar 31
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/60826
url http://hdl.handle.net/10810/60826
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.spiedigitallibrary.org/journals/neurophotonics
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
© The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License.
eu_rights_str_mv openAccess
rights_invalid_str_mv © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License.
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv SPIE.DIGITAL LIBRARY
publisher.none.fl_str_mv SPIE.DIGITAL LIBRARY
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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