Clinical and brain volumetric correlates of decreased DTI-ALPS, suggestive of local glymphatic dysfunction, in iRBD

Glymphatic alterations may underlie neurodegeneration in alpha-synucleinopathies. Reduced Diffusion-Tensor Imaging ALong the Perivascular Space (DTI-ALPS), a proxy of perivascular glymphatic activity, has been scarcely studied in isolated REM sleep behaviour disorder (iRBD), a prodromal synucleinopa...

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Detalles Bibliográficos
Autores: Roura, Ignacio, Pardo, Jèssica, Martín Barceló, Cristina, Falcón Falcón, Carles Maria, Oltra González, Javier, Campabadal Delgado, Anna, Bargalló Alabart, Núria, Serradell, Mónica, Mayà Casalprim, Gerard, Montini, Angelica, Pont Sunyer. Claustre, Gaig Ventura, Carles, Buongiorno, Maria Teresa, Junqué i Plaja, Carme, 1955-, Iranzo, Alex, Segura i Fàbregas, Bàrbara
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/226938
Acceso en línea:https://hdl.handle.net/2445/226938
Access Level:acceso abierto
Palabra clave:Neurologia
Degeneració (Patologia)
Cervell
Neurology
Degeneration (Pathology)
Brain
Descripción
Sumario:Glymphatic alterations may underlie neurodegeneration in alpha-synucleinopathies. Reduced Diffusion-Tensor Imaging ALong the Perivascular Space (DTI-ALPS), a proxy of perivascular glymphatic activity, has been scarcely studied in isolated REM sleep behaviour disorder (iRBD), a prodromal synucleinopathy stage. Furthermore, its associations with clinical symptoms and brain structural abnormalities remain unexplored. We assessed the DTI-ALPS in sixty-two patients with iRBD and twenty-three healthy controls (HC), exploring its associations with clinical symptoms, cortical thickness and brain volumetric data. iRBD patients exhibited a lower DTI-ALPS and poorer odor identification, semantic fluency and processing speed relative to HC. The DTI-ALPS positively correlated with cognitive performance, olfactory function and amygdalar, hippocampal, brainstem and diencephalic volumes, and negatively with age in iRBD. Perivascular glymphatic activity is compromised in iRBD and is associated with brain atrophy and clinical risk factors of progression to alpha-synucleinopathies, supporting the potential of the DTI-ALPS index as an early imaging neurodegeneration marker.

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