Monocyte subsets and serum inflammatory and bone-associated markers in monoclonal gammopathy of undetermined significance and multiple myeloma

We investigated the distribution of different subsets of monocytes (Mo) in blood and bone marrow (BM) of newly-diagnosed untreated monoclonal gammopathy of undetermined significance (MGUS), smoldering (SMM) and active multiple myeloma (MM), and its relationship with immune/bone serum-marker profiles...

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Authors: Damasceno, D. (Daniela)|||/items/d9ffdda2-2e8e-4e95-aad3-4cebdc026a5f, Almeida, J. (J.)|||/items/3ab7752e-6704-4ac0-8f19-68858ba743b8, Teodosio, C. (Cristina)|||/items/359a0f63-d562-49da-9ca2-f962c9c854ee, Sanoja-Flores, L. (L.)|||/items/36ab0b48-1001-415c-bc3e-b80ff31ab36e, Mayado, A. (Andrea)|||/items/3d0bc55f-f0df-48cd-8db1-ff5a8f30dd2b, Pérez-Pons, A. (Alba)|||/items/6ed321af-2186-4259-ae18-f9972999fdc6, Puig, N. (Noemí)|||/items/6ff3624a-2657-4823-b2a4-68b3f7b42ba2, Arana, P. (Paula)|||/items/4371fada-2950-413e-b050-3de272e7249f, Paiva, B. (Bruno)|||/items/b2c3efc5-27e1-4425-b452-efba1522c1d5, Solano, F. (Fernando)|||/items/dd0d7e5c-874c-42c4-84a3-4a1666db7434, Romero, A. (Alfonso)|||/items/6a07fbe1-e2e5-4961-b662-2ac609173dfd, Matarraz, S. (Sergio)|||/items/e96340ed-b501-444d-8a84-41d9d3cc6b80, Bossche, W.B.L. (Wouter B.L.) van den|||/items/26ed94fd-3c8a-45dd-b9d2-78b80321f528, Flores-Montero, J. (Juan)|||/items/4da510b1-fa31-4a7c-922c-de496ab7630a, Durie, B. (B.)|||/items/556fe9f6-7f87-475f-925f-e56cb347dac2, Dongen, J.J.M. (Jacques J. M.) van|||/items/f963fa8f-c9ec-46fc-b8b3-c7b88e1444cc, Orfao, A. (Alberto)|||/items/7ed3636b-0c92-4f3f-aed7-a9894c59af83
Format: article
Publication Date:2021
Country:España
Institution:Universidad de Navarra
Repository:Dadun. Depósito Académico Digital de la Universidad de Navarra
Language:English
OAI Identifier:oai:dadun.unav.edu:10171/112460
Online Access:https://hdl.handle.net/10171/112460
Access Level:Open access
Keyword:Plasma cell neoplasms
MGUS
Multiple myeloma
Monocytes
FcεRI monocytes
Tumor microenvironment
Inflammatory cytokines
Immunosenescence
Bone markers
Description
Summary:We investigated the distribution of different subsets of monocytes (Mo) in blood and bone marrow (BM) of newly-diagnosed untreated monoclonal gammopathy of undetermined significance (MGUS), smoldering (SMM) and active multiple myeloma (MM), and its relationship with immune/bone serum-marker profiles. Our results showed decreased production of BM Mo with decreased counts of classical Mo (cMo) in BM and blood of SMM and MM, but not MGUS. Conversely, intermediate and non-classical Mo were significantly increased in MGUS, SMM and MM BM. In parallel, increased levels of interleukin (IL)1β were observed in a fraction of MGUS and SMM, while increased serum IL8 was characteristic of SMM and MM, and higher serum IL6, RANKL and bone alkaline phosphatase concentrations, together with decreased counts of FcεRI+ cMo, were restricted to MM presenting with bone lesions. These results provide new insights in the pathogenesis of plasma cell neoplasms and the potential role of FcεRI+ cMo in normal bone homeostasis.

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