Are Advanced Glycation End Products in Skin Associated with Vascular Dysfunction Markers? A Meta-Analysis

Evidence exists regarding the association between advanced glycation end products and different cardiovascular disease subclinical processes, such as arterial stiffness and atherosclerosis. With this systematic review and meta-analysis, we aimed to provide a synthesis of the evidence regarding the a...

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Authors: Saz Lara, Alicia, Álvarez Bueno, Celia, Martínez Vizcaíno, Vicente José Anastasio, Notario Pacheco, Blanca, Sequí Domínguez, Irene, Cavero Redondo, Iván
Format: article
Publication Date:2020
Country:España
Institution:Universidad de Castilla-La Mancha
Repository:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/47431
Online Access:https://hdl.handle.net/10578/47431
Access Level:Open access
Keyword:Advanced glycation end products
Arterial stiffness
Cardiovascular disease
Carotid intima media thickness
Pulse wave velocity
Skin autofluorescence
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spelling Are Advanced Glycation End Products in Skin Associated with Vascular Dysfunction Markers? A Meta-AnalysisSaz Lara, AliciaÁlvarez Bueno, CeliaMartínez Vizcaíno, Vicente José AnastasioNotario Pacheco, BlancaSequí Domínguez, IreneCavero Redondo, IvánAdvanced glycation end productsArterial stiffnessCardiovascular diseaseCarotid intima media thicknessPulse wave velocitySkin autofluorescenceEvidence exists regarding the association between advanced glycation end products and different cardiovascular disease subclinical processes, such as arterial stiffness and atherosclerosis. With this systematic review and meta-analysis, we aimed to provide a synthesis of the evidence regarding the association of arterial stiffness measured by pulse wave velocity and atherosclerosis measured by carotid intima media thickness with skin autofluorescence. A systematic search was performed using: MEDLINE (PubMed), SCOPUS, and Web of Science, until 30 March 2020. Cross-sectional studies or baseline data from prospective longitudinal studies were considered. The DerSimonian and Laird method was used to calculate the pooled estimates of correlation coefficients and the corresponding 95% confidence intervals (CI) for the association of pulse wave velocity and carotid intima media thickness with skin autofluorescence. Twenty-five studies were included in the systematic review and meta-analysis, including 6306 subjects. The pooled correlation coefficient was 0.25 (95% CI: 0.18, 0.31) for pulse wave velocity and skin autofluorescence, and 0.31 (95% CI: 0.25, 0.38) for carotid intima media thickness and skin autofluorescence. This systematic review and meta-analysis provide a synthesis of the evidence showing a positive weak association of pulse wave velocity and carotid intima media thickness with skin autofluorescence.MDPI202620262020info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://hdl.handle.net/10578/47431reponame:RUIdeRA. Repositorio Institucional de la UCLMinstname:Universidad de Castilla-La ManchaInglés2019-PREDUCLM-10708info:eu-repo/semantics/openAccessoai:ruidera.uclm.es:10578/474312026-05-27T07:36:41Z
dc.title.none.fl_str_mv Are Advanced Glycation End Products in Skin Associated with Vascular Dysfunction Markers? A Meta-Analysis
title Are Advanced Glycation End Products in Skin Associated with Vascular Dysfunction Markers? A Meta-Analysis
spellingShingle Are Advanced Glycation End Products in Skin Associated with Vascular Dysfunction Markers? A Meta-Analysis
Saz Lara, Alicia
Advanced glycation end products
Arterial stiffness
Cardiovascular disease
Carotid intima media thickness
Pulse wave velocity
Skin autofluorescence
title_short Are Advanced Glycation End Products in Skin Associated with Vascular Dysfunction Markers? A Meta-Analysis
title_full Are Advanced Glycation End Products in Skin Associated with Vascular Dysfunction Markers? A Meta-Analysis
title_fullStr Are Advanced Glycation End Products in Skin Associated with Vascular Dysfunction Markers? A Meta-Analysis
title_full_unstemmed Are Advanced Glycation End Products in Skin Associated with Vascular Dysfunction Markers? A Meta-Analysis
title_sort Are Advanced Glycation End Products in Skin Associated with Vascular Dysfunction Markers? A Meta-Analysis
dc.creator.none.fl_str_mv Saz Lara, Alicia
Álvarez Bueno, Celia
Martínez Vizcaíno, Vicente José Anastasio
Notario Pacheco, Blanca
Sequí Domínguez, Irene
Cavero Redondo, Iván
author Saz Lara, Alicia
author_facet Saz Lara, Alicia
Álvarez Bueno, Celia
Martínez Vizcaíno, Vicente José Anastasio
Notario Pacheco, Blanca
Sequí Domínguez, Irene
Cavero Redondo, Iván
author_role author
author2 Álvarez Bueno, Celia
Martínez Vizcaíno, Vicente José Anastasio
Notario Pacheco, Blanca
Sequí Domínguez, Irene
Cavero Redondo, Iván
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Advanced glycation end products
Arterial stiffness
Cardiovascular disease
Carotid intima media thickness
Pulse wave velocity
Skin autofluorescence
topic Advanced glycation end products
Arterial stiffness
Cardiovascular disease
Carotid intima media thickness
Pulse wave velocity
Skin autofluorescence
description Evidence exists regarding the association between advanced glycation end products and different cardiovascular disease subclinical processes, such as arterial stiffness and atherosclerosis. With this systematic review and meta-analysis, we aimed to provide a synthesis of the evidence regarding the association of arterial stiffness measured by pulse wave velocity and atherosclerosis measured by carotid intima media thickness with skin autofluorescence. A systematic search was performed using: MEDLINE (PubMed), SCOPUS, and Web of Science, until 30 March 2020. Cross-sectional studies or baseline data from prospective longitudinal studies were considered. The DerSimonian and Laird method was used to calculate the pooled estimates of correlation coefficients and the corresponding 95% confidence intervals (CI) for the association of pulse wave velocity and carotid intima media thickness with skin autofluorescence. Twenty-five studies were included in the systematic review and meta-analysis, including 6306 subjects. The pooled correlation coefficient was 0.25 (95% CI: 0.18, 0.31) for pulse wave velocity and skin autofluorescence, and 0.31 (95% CI: 0.25, 0.38) for carotid intima media thickness and skin autofluorescence. This systematic review and meta-analysis provide a synthesis of the evidence showing a positive weak association of pulse wave velocity and carotid intima media thickness with skin autofluorescence.
publishDate 2020
dc.date.none.fl_str_mv 2020
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10578/47431
url https://hdl.handle.net/10578/47431
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv 2019-PREDUCLM-10708
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:RUIdeRA. Repositorio Institucional de la UCLM
instname:Universidad de Castilla-La Mancha
instname_str Universidad de Castilla-La Mancha
reponame_str RUIdeRA. Repositorio Institucional de la UCLM
collection RUIdeRA. Repositorio Institucional de la UCLM
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419350110240768
score 15.811543

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