DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells

[Background]: Conventional type 1 dendritic cells (cDC1s) are central to antitumor immunity and their presence in the tumor microenvironment associates with improved outcomes in patients with cancer. DNGR-1 (CLEC9A) is a dead cell-sensing receptor highly restricted to cDC1s. DNGR-1 has been involved...

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Detalhes bibliográficos
Autores: Cueto, Francisco J., Fresno, Carlos del, Brandi, Paola, Combes, Alexis J., Hernández-García, Elena, Sánchez-Paulete, Alfonso R., Enamorado, Michel, Bromley, Christian P, Gómez, Manuel José, Conde-Garrosa, Ruth, Mañes, Santos, Zelenay, Santiago, Melero, Ignacio, Iborra, Salvador, Krummel, Matthew F., Sancho, David
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/304540
Acesso em linha:http://hdl.handle.net/10261/304540
https://api.elsevier.com/content/abstract/scopus_id/85105841820
Access Level:acceso abierto
Palavra-chave:http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
Descrição
Resumo:[Background]: Conventional type 1 dendritic cells (cDC1s) are central to antitumor immunity and their presence in the tumor microenvironment associates with improved outcomes in patients with cancer. DNGR-1 (CLEC9A) is a dead cell-sensing receptor highly restricted to cDC1s. DNGR-1 has been involved in both cross-presentation of dead cell-associated antigens and processes of disease tolerance, but its role in antitumor immunity has not been clarified yet.

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