A Low Noise Amplifier for Neural Spike Recording Interfaces

This paper presents a Low Noise Amplifier (LNA) for neural spike recording applications. The proposed topology, based on a capacitive feedback network using a two-stage OTA, efficiently solves the triple trade-off between power, area and noise. Additionally, this work introduces a novel transistor-l...

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Detalles Bibliográficos
Autores: Ruiz Amaya, Jesús, Rodríguez Pérez, Alberto, Delgado Restituto, Manuel 
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/74310
Acceso en línea:https://hdl.handle.net/11441/74310
https://doi.org/10.3390/s151025313
Access Level:acceso abierto
Palabra clave:Low-Noise Amplifier
Neural spike recording
Biomedical circuit
Circuit sizing
Descripción
Sumario:This paper presents a Low Noise Amplifier (LNA) for neural spike recording applications. The proposed topology, based on a capacitive feedback network using a two-stage OTA, efficiently solves the triple trade-off between power, area and noise. Additionally, this work introduces a novel transistor-level synthesis methodology for LNAs tailored for the minimization of their noise efficiency factor under area and noise constraints. The proposed LNA has been implemented in a 130 nm CMOS technology and occupies 0.053 mm-sq. Experimental results show that the LNA offers a noise efficiency factor of 2.16 and an input referred noise of 3.8 Vrms for 1.2 V power supply. It provides a gain of 46 dB over a nominal bandwidth of 192 Hz–7.4 kHz and consumes 1.92 W. The performance of the proposed LNA has been validated through in vivo experiments with animal models