ACE-Vitamin Index and Risk of Glaucoma: the SUN Project

Background: Previous studies regarding antioxidant consumption and glaucoma have shown contradictory results. The aim of this study was to analyze the combined effect of the consumption of three vitamins (A, C and E) on the incidence of glaucoma in the SUN Project. Methods: For this study, 18,669 pa...

ver descrição completa

Detalhes bibliográficos
Autores: Moreno-Montañes, J. (Javier)|||/items/98d37454-a942-4359-9367-75c9948f0834, Gándara-Rodríguez-de-Campoamor, E. (Elsa)|||/items/bcfe203b-f80c-4118-840f-3c8b6c5cfeed, Moreno-Galarraga, L. (Laura)|||/items/3583c276-7f01-47e6-8c87-e583043a1c1f, Hershey-de-la-Cruz, M.S. (María Soledad)|||/items/32d1f371-99a2-4b2a-a1da-737278a5fb18, López-Gil, J.F. (José Francisco)|||/items/642fa46c-6169-49e7-87c8-a934e9c27563, Kales, S.N. (Stefanos N.)|||/items/e8c58bd7-cb4a-4009-a2b5-4b981584d5f9, Bes-Rastrollo, M. (Maira)|||/items/d46c05fd-209a-4259-90c6-07202d4c72af, Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7, Fernandez-Montero, A. (Alejandro)|||/items/0d23602b-1c19-44e7-b698-bf919bed4ea7
Formato: artículo
Fecha de publicación:2022
País:España
Recursos:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/65285
Acesso em linha:https://hdl.handle.net/10171/65285
Access Level:acceso abierto
Palavra-chave:Vitamin A
Vitamin C
Vitamin E
Glaucoma
SUN project
Descrição
Resumo:Background: Previous studies regarding antioxidant consumption and glaucoma have shown contradictory results. The aim of this study was to analyze the combined effect of the consumption of three vitamins (A, C and E) on the incidence of glaucoma in the SUN Project. Methods: For this study, 18,669 participants were included. The mean follow-up was 11.5 years. An index including vitamins A, C and E (ACE-Vitamin Index) was calculated. Vitamin intake was extracted from participants' dietary data and vitamin supplements, if taken. Information on glaucoma incidence was collected by previously validated self-reported questionnaires. The association between glaucoma and vitamin intake was assessed by repeated-measures Cox regression using multi-adjusted hazard ratios. Results: A total of 251 (1.3%) cases of glaucoma were detected. Participants with a higher ACE-Vitamin Index presented a reduced risk of glaucoma compared to participants with lower consumption (adjusted HR = 0.73; 95% CI, (0.55-0.98)). When each vitamin was analyzed individually, none of them had a significant protective effect. The protective effect of the ACE-Vitamin Index was higher in men and older participants (>= 55 year). Conclusions: The consumption of vitamins A, C and E considered separately do not seem to exert a protective effect against glaucoma, but when these vitamins are considered together, they are associated with a lower risk of glaucoma.

Registos relacionados