Efficacy of proton pump inhibitor therapy for eosinophilic oesophagitis in 630 patients: results from the EoE connect registry

Background: Proton pump inhibitors (PPIs) are the most commonly used first-line therapy for patients with eosinophilic oesophagitis (EoE). However, many aspects related to PPIs in EoE are still unknown. Aims: To assess the effectiveness of PPI therapy for EoE in real-world practice. Methods: This cr...

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Detalhes bibliográficos
Autores: Laserna-Mendieta, E.J. (Emilio J.)|||/items/588ad109-4862-485d-bd43-1c90a60e0960, Casabona, S. (Sergio)|||/items/260b3b88-25cc-4d0b-a099-1f1daefcda51, Guagnozzi, D. (Danila)|||/items/0ff08dfd-e138-476e-bda8-48c95cccb479, Savarino, E. (Edoardo)|||/items/b7816791-446c-4354-9181-c163bacd92d2, Perelló, A. (Antonia)|||/items/098bf493-366b-425c-b91a-28618af33309, Guardiola-Arévalo, A. (Antonio)|||/items/2b091fb4-a7e1-4dff-9de2-3b39b071b8fd, Barrio-Barrio, J. (Jesús)|||/items/6143482b-0e50-4c28-b8a8-1bd192394f23, Pérez-Martínez, I. (Isabel)|||/items/d8cde6de-fc4d-4b26-a868-23b6cb1ed810, Krarup, A.L. (Anne Lund)|||/items/3612cf86-ad4f-4d72-9313-1126e8141766, Alcedo, J. (Javier)|||/items/5ea463b2-abdd-4eba-a445-3661d06eb520, Riva-Onandía, S.R. (Susana Rosa) de la|||/items/47afe9de-f448-4be6-baf5-c5ef663fc8b3, Rey, E. (Esther)|||/items/b3b1957c-2a96-4aaa-92da-327bbb933a92, Santander, C. (Cecilio)|||/items/55b1687e-289e-46cf-a02d-4efb65f178f3, Arias-Urrutia, Á. (Ángel)|||/items/9aeff04b-899d-45a0-b957-b9753ed68c42, Lucendo, A.J. (Alfredo J.)|||/items/e800f299-9ece-460c-91c0-e8adb782f505
Tipo de documento: artigo
Data de publicação:2020
País:España
Recursos:Universidad de Navarra
Repositório:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglês
OAI Identifier:oai:dadun.unav.edu:10171/112939
Acesso em linha:https://hdl.handle.net/10171/112939
Access Level:Acceso aberto
Palavra-chave:Eosinophilic oesophagitis
Proton pump inhibitors
INTERDISCIPLINARY RESEARCH AREAS::Caring sciences::Occupational therapy
Descrição
Resumo:Background: Proton pump inhibitors (PPIs) are the most commonly used first-line therapy for patients with eosinophilic oesophagitis (EoE). However, many aspects related to PPIs in EoE are still unknown. Aims: To assess the effectiveness of PPI therapy for EoE in real-world practice. Methods: This cross-sectional study collected data on PPI efficacy from the multicentre EoE CONNECT database. Clinical remission was defined as a decrease of ≥50% in dysphagia symptom score; histological remission was defined as a peak eosinophil count below 15 eosinophils per high-power field. Factors associated with effectiveness of PPI therapy were identified by binary logistic regression multivariate analyses. Results: Overall, 630 patients (76 children) received PPI as initial therapy (n = 600) or after failure to respond to other therapies (n = 30). PPI therapy achieved eosinophil density below 15 eosinophils per high-power field in 48.8% and a decreased symptom score in 71.0% of patients. More EoE patients with an inflammatory rather than stricturing phenotype accomplished clinico-histological remission after PPI therapy (OR 3.7; 95% CI, 1.4-9.5); as well as those who prolonged treatment length from 8 to 12 weeks (OR 2.7; 95% CI, 1.3-5.3). After achieving clinico-histological remission of EoE, PPI dosage reduction was effectively maintained in 69.9% of patients, but tended to be less effective among those with a stricturing phenotype. Conclusions: Inflammatory EoE phenotype and treatment duration up to 12 weeks correlated with greater chance for inducing remission of EoE. A stricturing phenotype decreased response rates to PPI therapy both initially and in the long term.

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