Elastography is unable to exclude cirrhosis after sustained virological response in HCV-infected patients with advanced chronic liver disease

Background: Liver fibrosis and transient elastography (TE) correlation in hepatitis C virus (HCV)-infected patients with compensated advanced chronic liver disease (cACLD) after the sustained virological response (SVR) is unknown. Aims: To evaluate TE accuracy at identifying cirrhosis 3 years after...

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Detalhes bibliográficos
Autores: Broquetas, Teresa|||0000-0002-5935-3076, Herruzo-Pino, Paula, Mariño, Zoe|||0000-0001-6321-9534, Naranjo-Hans, Dolores|||0000-0002-4089-047X, Vergara, Mercedes|||0000-0002-6971-8657, Morillas Cunill, Rosa Ma|||0000-0001-9117-5049, Forns, Xavier|||0000-0002-8188-1764, Carrión Rodríguez, José Antonio|||0000-0001-7191-6081
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:251942
Acesso em linha:https://ddd.uab.cat/record/251942
https://dx.doi.org/urn:doi:10.1111/liv.15058
Access Level:acceso abierto
Palavra-chave:Cirrhosis
Fibrosis
Hepatitis C
Liver biopsy
Sustained virological response
Transient elastography
Descrição
Resumo:Background: Liver fibrosis and transient elastography (TE) correlation in hepatitis C virus (HCV)-infected patients with compensated advanced chronic liver disease (cACLD) after the sustained virological response (SVR) is unknown. Aims: To evaluate TE accuracy at identifying cirrhosis 3 years after HCV-eradication. Methods: Prospective, multi-centric study including HCV-cACLD patients before direct-acting antivirals (DAA). Diagnostic accuracy of TE (area under ROC, AUROC) to identify cirrhosis 3 years after SVR was evaluated. Results: Among 746 HCV-infected patients (95.4% with TE ≥10 kPa), 76 (10.2%) underwent a liver biopsy 3 years after SVR. Before treatment, 46 (63%) showed a TE

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