Cardiac Biomarker Release After Exercise in Healthy Children and Adolescents: A Systematic Review and Meta-Analysis

The authors evaluated the impact of acute exercise and 24-hour recovery on serum concentration of cardiac troponins T and I (cTnT and cTnI) and N-terminal fragment of the prohormone brain natriuretic peptide (NT-proBNP) in healthy children and adolescents. The authors also determined the proportion...

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Detalles Bibliográficos
Autores: Cirer-Sastre, Rafel, Legaz Arrese, Alejandro, Corbi Soler, Francesc, George, Keith, Nie, Jinlei, Carranza García, Luis E., Reverter Masià, Joaquín
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/65968
Acceso en línea:https://doi.org/10.1123/pes.2018-0058
http://hdl.handle.net/10459.1/65968
Access Level:acceso abierto
Palabra clave:Sport medicine
cTnT
cTnI
NT-proBNP
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spelling Cardiac Biomarker Release After Exercise in Healthy Children and Adolescents: A Systematic Review and Meta-AnalysisCirer-Sastre, RafelLegaz Arrese, AlejandroCorbi Soler, FrancescGeorge, KeithNie, JinleiCarranza García, Luis E.Reverter Masià, JoaquínSport medicinecTnTcTnINT-proBNPThe authors evaluated the impact of acute exercise and 24-hour recovery on serum concentration of cardiac troponins T and I (cTnT and cTnI) and N-terminal fragment of the prohormone brain natriuretic peptide (NT-proBNP) in healthy children and adolescents. The authors also determined the proportion of participants exceeding the upper reference limits and acute myocardial infarction cutoff for each assay. Method: Web of Science, SPORTDiscus, MEDLINE, ScienceDirect, and Scopus databases were systematically searched up to November 2017. Studies were screened and quality-assessed; the data was systematically extracted and analyzed. Results: From 751 studies initially identified, 14 met the inclusion criteria for data extraction. All 3 biomarkers were increased significantly after exercise. A decrease from postexercise to 24 hours was noted in cTnT and cTnI, although this decrease was only statistically significant for cTnT. The upper reference limit was exceeded by 76% of participants for cTnT, a 51% for cTnI, and a 13% for NT-proBNP. Furthermore, the cutoff value for acute myocardial infarction was exceeded by 39% for cTnT and a 11% for cTnI. Postexercise peak values of cTnT were associated with duration and intensity (Q(3) = 28.3, P < .001) while NT-proBNP peak values were associated with duration (Q(2) = 11.9, P = .003). Conclusion: Exercise results in the appearance of elevated levels of cTnT, cTnI, and NT-proBNP in children and adolescents. Postexercise elevations of cTnT and NT-proBNP are associated with exercise duration and intensity.Human Kinetics2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttps://doi.org/10.1123/pes.2018-0058http://hdl.handle.net/10459.1/65968reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésVersió postprint del document publicat a https://doi.org/10.1123/pes.2018-0058Pediatric Exercise Science, 2019, vol.31, núm. 1, p. 28-36(c) Human Kinetics, 2019info:eu-repo/semantics/openAccessoai:repositori.udl.cat:10459.1/659682026-06-24T12:42:17Z
dc.title.none.fl_str_mv Cardiac Biomarker Release After Exercise in Healthy Children and Adolescents: A Systematic Review and Meta-Analysis
title Cardiac Biomarker Release After Exercise in Healthy Children and Adolescents: A Systematic Review and Meta-Analysis
spellingShingle Cardiac Biomarker Release After Exercise in Healthy Children and Adolescents: A Systematic Review and Meta-Analysis
Cirer-Sastre, Rafel
Sport medicine
cTnT
cTnI
NT-proBNP
title_short Cardiac Biomarker Release After Exercise in Healthy Children and Adolescents: A Systematic Review and Meta-Analysis
title_full Cardiac Biomarker Release After Exercise in Healthy Children and Adolescents: A Systematic Review and Meta-Analysis
title_fullStr Cardiac Biomarker Release After Exercise in Healthy Children and Adolescents: A Systematic Review and Meta-Analysis
title_full_unstemmed Cardiac Biomarker Release After Exercise in Healthy Children and Adolescents: A Systematic Review and Meta-Analysis
title_sort Cardiac Biomarker Release After Exercise in Healthy Children and Adolescents: A Systematic Review and Meta-Analysis
dc.creator.none.fl_str_mv Cirer-Sastre, Rafel
Legaz Arrese, Alejandro
Corbi Soler, Francesc
George, Keith
Nie, Jinlei
Carranza García, Luis E.
Reverter Masià, Joaquín
author Cirer-Sastre, Rafel
author_facet Cirer-Sastre, Rafel
Legaz Arrese, Alejandro
Corbi Soler, Francesc
George, Keith
Nie, Jinlei
Carranza García, Luis E.
Reverter Masià, Joaquín
author_role author
author2 Legaz Arrese, Alejandro
Corbi Soler, Francesc
George, Keith
Nie, Jinlei
Carranza García, Luis E.
Reverter Masià, Joaquín
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Sport medicine
cTnT
cTnI
NT-proBNP
topic Sport medicine
cTnT
cTnI
NT-proBNP
description The authors evaluated the impact of acute exercise and 24-hour recovery on serum concentration of cardiac troponins T and I (cTnT and cTnI) and N-terminal fragment of the prohormone brain natriuretic peptide (NT-proBNP) in healthy children and adolescents. The authors also determined the proportion of participants exceeding the upper reference limits and acute myocardial infarction cutoff for each assay. Method: Web of Science, SPORTDiscus, MEDLINE, ScienceDirect, and Scopus databases were systematically searched up to November 2017. Studies were screened and quality-assessed; the data was systematically extracted and analyzed. Results: From 751 studies initially identified, 14 met the inclusion criteria for data extraction. All 3 biomarkers were increased significantly after exercise. A decrease from postexercise to 24 hours was noted in cTnT and cTnI, although this decrease was only statistically significant for cTnT. The upper reference limit was exceeded by 76% of participants for cTnT, a 51% for cTnI, and a 13% for NT-proBNP. Furthermore, the cutoff value for acute myocardial infarction was exceeded by 39% for cTnT and a 11% for cTnI. Postexercise peak values of cTnT were associated with duration and intensity (Q(3) = 28.3, P < .001) while NT-proBNP peak values were associated with duration (Q(2) = 11.9, P = .003). Conclusion: Exercise results in the appearance of elevated levels of cTnT, cTnI, and NT-proBNP in children and adolescents. Postexercise elevations of cTnT and NT-proBNP are associated with exercise duration and intensity.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1123/pes.2018-0058
http://hdl.handle.net/10459.1/65968
url https://doi.org/10.1123/pes.2018-0058
http://hdl.handle.net/10459.1/65968
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a https://doi.org/10.1123/pes.2018-0058
Pediatric Exercise Science, 2019, vol.31, núm. 1, p. 28-36
dc.rights.none.fl_str_mv (c) Human Kinetics, 2019
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Human Kinetics, 2019
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Human Kinetics
publisher.none.fl_str_mv Human Kinetics
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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