ALK-Fusion Transcripts Can Be Detected in Extracellular Vesicles (EVs) from Nonsmall Cell Lung Cancer Cell Lines and Patient Plasma: Toward EV-Based Noninvasive Testing

[Background]: ALK rearrangements are present in 5% of nonsmall cell lung cancer (NSCLC) tumors and identify patients who can benefit from ALK inhibitors. ALK fusions testing using liquid biopsies, although challenging, can expand the therapeutic options for ALK-positive NSCLC patients considerably....

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Authors: Sánchez-Herrero, Estela, Campos-Silva, Carmen, Cáceres-Martell, Yaiza, Robado de Lope, Lucía, Sanz-Moreno, Sandra, Serna-Blasco, Roberto, Rodríguez-Festa, Alejandro, Ares Trotta, Dunixe, Martín-Acosta, Paloma, Patiño, Cristina, Coronado, María José, Beneítez-Martínez, Alexandra, Jara, Ricardo, Lago-Baameiro, Nerea, Camino, Tamara, Cruz-Bermúdez, Alberto, Pardo, María, González-Rumayor, Víctor, Valés-Gómez, Mar, Provencio, Mariano, Romero, Atocha
Format: article
Status:Published version
Publication Date:2022
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/346457
Online Access:http://hdl.handle.net/10261/346457
Access Level:Open access
Keyword:ALK-TKI
EML4-ALK
Extracellular vesicles
Liquid biopsy
NSCLC
Description
Summary:[Background]: ALK rearrangements are present in 5% of nonsmall cell lung cancer (NSCLC) tumors and identify patients who can benefit from ALK inhibitors. ALK fusions testing using liquid biopsies, although challenging, can expand the therapeutic options for ALK-positive NSCLC patients considerably. RNA inside extracellular vesicles (EVs) is protected from RNases and other environmental factors, constituting a promising source for noninvasive fusion transcript detection.

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