A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin
In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the DEAD-box helicase 5 (DDX5) at DNA breaks that promotes unwinding DNA-RNA hybrids within transcribed chromatin and favors repair. Interestingly, BRCA2–DDX5 interaction is impaired in...
| Autores: | , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión enviada para evaluación y publicación |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad de Sevilla (US) |
| Repositorio: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:idus.us.es:11441/125296 |
| Acceso en línea: | https://hdl.handle.net/11441/125296 https://doi.org/10.1080/23723556.2021.1910474 |
| Access Level: | acceso abierto |
| Palabra clave: | BRCA2 Breast cancer DDX5 DNA-RNA hybrid Double-strand break DSB repair Homologous recombination |
| Sumario: | In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the DEAD-box helicase 5 (DDX5) at DNA breaks that promotes unwinding DNA-RNA hybrids within transcribed chromatin and favors repair. Interestingly, BRCA2–DDX5 interaction is impaired in cells expressing the BRCA2T207A missense variant found in breast cancer patients. |
|---|