Rearrangements involving 11q23.3/KMT2A in adult AML

Balanced rearrangements involving the KMT2A gene (KMT2Ar) are recurrent genetic abnormalities in acute myeloid leukemia (AML), but there is lack of consensus regarding the prognostic impact of different fusion partners. Moreover, prognostic implications of gene mutations co-occurring with KMT2Ar are...

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Autores: Hernández-Sánchez, A., González, T., Sobas, M., Sträng, E., Castellani, Gastone|||0000-0003-4892-925X, Abáigar Alvarado, María|||0000-0002-5716-6242, Valk, Peter J. M.|||0000-0002-8857-9461, Villaverde Ramiro, Ángela|||0000-0002-7337-7218, Benner, Axel|||0000-0002-7238-6956, Metzeler, Klaus H.|||0000-0003-3920-7490, Azibeiro, Raúl, Tettero, JM.|||0000-0002-0811-0824, Martínez-López, Joaquín|||0000-0001-7908-0063, Pratcorona, Marta|||0000-0001-6375-596X, Martínez Elicegui, Javier|||0000-0001-5294-6162, Mills, Ken|||0000-0002-6362-4481, Thiede, Christian|||0000-0003-1241-2048, Sanz, Guillermo|||0000-0002-2767-8191, Döhner, Konstanze|||0000-0002-2261-9862, Heuser, Michael|||0000-0001-5318-9044, Haferlach, T.|||0000-0003-0196-2837, Turki, Amin|||0000-0003-1347-3360, Reinhardt, Dirk, Schulze-Rath, Renate, Barbus, Martje, Hernández Rivas, Jesús María|||0000-0002-9661-9371, Huntly, Brian|||0000-0003-0312-161X, Ossenkoppele, Gert, Döhner, Hartmut|||0000-0003-2116-5536, Bullinger, Lars|||0000-0002-5890-5510
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:308094
Acceso en línea:https://ddd.uab.cat/record/308094
https://dx.doi.org/urn:doi:10.1038/s41375-024-02333-4
Access Level:acceso abierto
Palabra clave:Adolescent
Adult
Aged
Aged, 80 and over
Chromosomes, Human, Pair 11
Female
Gene Rearrangement
High-Throughput Nucleotide Sequencing
Histone-Lysine N-Methyltransferase
Humans
Leukemia, Myeloid, Acute
Male
Middle Aged
Mutation
Myeloid-Lymphoid Leukemia Protein
Prognosis
Survival Rate
Translocation, Genetic
Young Adult
Descripción
Sumario:Balanced rearrangements involving the KMT2A gene (KMT2Ar) are recurrent genetic abnormalities in acute myeloid leukemia (AML), but there is lack of consensus regarding the prognostic impact of different fusion partners. Moreover, prognostic implications of gene mutations co-occurring with KMT2Ar are not established. From the HARMONY AML database 205 KMT2Ar adult patients were selected, 185 of whom had mutational information by a panel-based next-generation sequencing analysis. Overall survival (OS) was similar across the different translocations, including t(9;11)(p21.3;q23.3)/KMT2A::MLLT3 (p = 0.756). However, independent prognostic factors for OS in intensively treated patients were age.

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