First-line PARP inhibitors in ovarian cancer: summary of an ESMO Open - Cancer Horizons round-table discussion

Poly(ADP-ribose) polymerase (PARP) inhibitor maintenance therapy is the latest breakthrough in the management of newly diagnosed advanced ovarian cancer. The results of the SOLO-1 trial in 2018 led to European Medicines Agency and Food and Drug Administration approval of olaparib as first-line maint...

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Authors: Banerjee, S. (S.)|||/items/f5c09af3-2520-48db-abd8-8855a3ed433b, González-Martín, A. (Antonio)|||/items/47e72e63-32d3-4a8a-91d5-2624d704fb4e, Harter, P. (P.)|||/items/262661b2-4b5b-463b-a599-bbc50796f3ca, Lorusso, D. (D.)|||/items/5521a7ff-eab6-43d6-8b5e-4fa7b81a14d1, Moore, K.N. (Kathleen N.)|||/items/a31fd5ac-b9e2-4f6e-b95d-ec472e56bb20, Oaknin, A. (Ana)|||/items/d1146e12-acc1-429a-9660-4e47d0b84e37, Ray-Coquard, I. (Isabelle)|||/items/942f3eb2-dcc1-4420-a88b-4222f6aeec45
Format: article
Publication Date:2020
Country:España
Institution:Universidad de Navarra
Repository:Dadun. Depósito Académico Digital de la Universidad de Navarra
Language:English
OAI Identifier:oai:dadun.unav.edu:10171/66621
Online Access:https://hdl.handle.net/10171/66621
Access Level:Open access
Keyword:PARP inhibitorsadvanced
Ovarian cancer
Description
Summary:Poly(ADP-ribose) polymerase (PARP) inhibitor maintenance therapy is the latest breakthrough in the management of newly diagnosed advanced ovarian cancer. The results of the SOLO-1 trial in 2018 led to European Medicines Agency and Food and Drug Administration approval of olaparib as first-line maintenance therapy in patients with BRCA1/2 mutation, establishing a new standard of care. Subsequently, the results of three phase III trials (PRIMA, PAOLA-1, VELIA) evaluating the use of first-line PARP inhibitors beyond patients with BRCA1/2 mutations and as combination strategies were presented in 2019, leading to the recent approval of maintenance niraparib irrespective of biomarker status and olaparib in combination with bevacizumab in homologous recombination deficiencypositive-associated advanced ovarian cancer. An ESMO Open - Cancer Horizons round-table expert panel discussed the four phase III trials of first-line PARP inhibitor therapy and how they are changing the clinical management of advanced ovarian cancer.

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