Circulating Soluble CD36 is Similar in Type 1 and Type 2 Diabetes Mellitus versus Non-Diabetic Subjects

The aim of this study was to determine whether plasma concentrations of sCD36 (soluble CD36) are associated with the presence of type 1 or type 2 diabetes. Plasma levels of sCD36 were analysed in 1023 subjects (225 type 1 diabetes (T1D) patients, 276 type 2 diabetes (T2D) patients, and 522non-diabet...

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Detalhes bibliográficos
Autores: Castelblanco Echavarría, Esmeralda, Sanjurjo, Lucía, Falguera, Mireia, Hernández García, Marta, Fernández Real, José Manuel, Sarrias, Maria-Rosa, Alonso, Núria, Mauricio Puente, Dídac
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Recursos:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/67766
Acesso em linha:https://doi.org/10.3390/jcm8050710
http://hdl.handle.net/10459.1/67766
Access Level:acceso abierto
Palavra-chave:sCD36
Type 1 diabetes mellitus
Type 2 diabetes mellitus
Descrição
Resumo:The aim of this study was to determine whether plasma concentrations of sCD36 (soluble CD36) are associated with the presence of type 1 or type 2 diabetes. Plasma levels of sCD36 were analysed in 1023 subjects (225 type 1 diabetes (T1D) patients, 276 type 2 diabetes (T2D) patients, and 522non-diabeticcontrolsubjects)usinganenzyme-linkedimmunosorbentassay(ELISA).Multinomial andlogisticregressionmodelswereperformedtoevaluateassociationswithsCD36anditsassociation with diabetes types. There were no significant differences in sCD36 (p = 0.144) among study groups, neither in head-to-head comparisons: non-diabetic versus T1D subjects (p = 0.180), non-diabetic versus T2D subjects (p = 0.583), and T1D versus T2D patients (p = 0.151). In the multinomial model, lower sCD36 concentrations were associated with older age (p < 0.001), tobacco exposure (p = 0.006), T2D (p = 0.020), and a higher-platelets count (p = 0.004). However, in logistic regression models of diabetes, sCD36 showed only a weak association with T2D. The current findings show a weak association of circulating sCD36 with type 2 diabetes and no association with T1D.

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