Human amyloid-β enriched extracts: evaluation of in vitro and in vivo internalization and molecular characterization

[Background]: Intracerebral inoculation of extracts from post-mortem human Alzheimer’s disease brains into mice produces a prion-like spreading effect of amyloid-β. The differences observed between these extracts and the synthetic peptide, in terms of amyloid-β internalization and seed and cell-to-c...

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Detalles Bibliográficos
Autores: Pedrero-Prieto, Cristina M., Flores-Cuadrado, Alicia, Saiz-Sánchez, Daniel, Úbeda-Bañón, Isabel, Frontiñán-Rubio, Javier, Alcaín, Francisco J., Mateos-Hernández, Lourdes, Fuente, José de la, Durán-Prado, Mario, Villar, Margarita, Martínez-Marcos, Alino, Peinado, Juan R.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/215742
Acceso en línea:http://hdl.handle.net/10261/215742
Access Level:acceso abierto
Palabra clave:Alzheimer’s disease
Amyloid-β
Prion-like hypothesis
Amyloid-β internalization
Proteomics
Descripción
Sumario:[Background]: Intracerebral inoculation of extracts from post-mortem human Alzheimer’s disease brains into mice produces a prion-like spreading effect of amyloid-β. The differences observed between these extracts and the synthetic peptide, in terms of amyloid-β internalization and seed and cell-to-cell transmission of cytosolic protein aggregates, suggest that brain extracts contain key contributors that enhance the prion-like effect of amyloid-β. Nevertheless, these potential partners are still unknown due to the complexity of whole brain extracts.

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