Ivermectin vs moxidectin for treating Strongyloides stercoralis infection : a systematic review

The aim was to assess the efficacy of ivermectin vs moxidectin for treating Strongyloides stercoralis infection. Ovid MEDLINE, Embase and Web of Science databases were searched for studies comparing ivermectin and moxidectin from inception to February 2024. The outcomes: elimination of infection or...

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Detalhes bibliográficos
Autores: Henriquez-Camacho, Cesar, Pérez-Molina, Jose A., Buonfrate, Dora, Rodari, Paola, Gotuzzo, Eduardo, Luengo, Benilde, Plana, María Nieves
Formato: artículo
Fecha de publicación:2024
País:España
Recursos:Universidad de Málaga
Repositorio:DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
Idioma:inglés
OAI Identifier:oai:ddfv.ufv.es:10641/6341
Acesso em linha:https://hdl.handle.net/10641/6341
Access Level:acceso abierto
Palavra-chave:Strongyloides stercoralis
ivermectin
moxidectin
parasitological cure
Parasitology
Animal Science and Zoology
Infectious Diseases
SDG 3 - Good Health and Well-being
Journal Article
Systematic Review
Comparative Study
Yes
yes
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spelling Ivermectin vs moxidectin for treating Strongyloides stercoralis infection : a systematic reviewHenriquez-Camacho, CesarPérez-Molina, Jose A.Buonfrate, DoraRodari, PaolaGotuzzo, EduardoLuengo, BenildeLuengo, BenildePlana, María NievesStrongyloides stercoralisivermectinmoxidectinparasitological cureParasitologyAnimal Science and ZoologyInfectious DiseasesSDG 3 - Good Health and Well-beingJournal ArticleSystematic ReviewComparative StudyYesyesThe aim was to assess the efficacy of ivermectin vs moxidectin for treating Strongyloides stercoralis infection. Ovid MEDLINE, Embase and Web of Science databases were searched for studies comparing ivermectin and moxidectin from inception to February 2024. The outcomes: elimination of infection or parasitological cure, mortality and serious adverse events. We calculated odds ratios (ORs) with 95% confidence intervals (CIs) for dichotomous data. Heterogeneity was assessed using Chi2 test for statistical heterogeneity and results of the I2 statistic. Two trials met the inclusion criteria that included 821 adult participants. Both studies were conducted in southeast Asia (Cambodia and Laos). Neither trial included immunocompromised patients. The mean age of the participants ranged from 40 to 45 years old, with a similar distribution of males and females. For all participants, S. stercoralis infection was confirmed by Baermann method. The evidence was moderate for parasitological cure rate. Certainty was downgraded by 1 level because of imprecision. Moxidectin was not inferior to ivermectin: OR 0.67, 95% CI 0.36-1.25 (P = 0.21), I2 = 0%, 821 participants. No deaths were reported in either trial. One trial reported mild adverse events. In total, 153/726 (21%) participants had an adverse event. The most reported symptoms were abdominal pain and headache. There is evidence for moderate quality that moxidectin is non-inferior to, and as safe as ivermectin; however, more high-quality and well-designed trials are needed. For patients with some underlying immunosuppressive disorder, or in patients who are very young or very old, current data are insufficient to be recommended.Facultad de MedicinaBiblioteca20242024-11-0120242024-11-01review articlehttp://purl.org/coar/resource_type/c_dcae04bcinfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10641/6341reponame:DDFV. Repositorio Institucional de la Universidad Francisco de Vitoriainstname:Universidad de MálagaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddfv.ufv.es:10641/63412026-06-11T12:44:57Z
dc.title.none.fl_str_mv Ivermectin vs moxidectin for treating Strongyloides stercoralis infection : a systematic review
title Ivermectin vs moxidectin for treating Strongyloides stercoralis infection : a systematic review
spellingShingle Ivermectin vs moxidectin for treating Strongyloides stercoralis infection : a systematic review
Henriquez-Camacho, Cesar
Strongyloides stercoralis
ivermectin
moxidectin
parasitological cure
Parasitology
Animal Science and Zoology
Infectious Diseases
SDG 3 - Good Health and Well-being
Journal Article
Systematic Review
Comparative Study
Yes
yes
title_short Ivermectin vs moxidectin for treating Strongyloides stercoralis infection : a systematic review
title_full Ivermectin vs moxidectin for treating Strongyloides stercoralis infection : a systematic review
title_fullStr Ivermectin vs moxidectin for treating Strongyloides stercoralis infection : a systematic review
title_full_unstemmed Ivermectin vs moxidectin for treating Strongyloides stercoralis infection : a systematic review
title_sort Ivermectin vs moxidectin for treating Strongyloides stercoralis infection : a systematic review
dc.creator.none.fl_str_mv Henriquez-Camacho, Cesar
Pérez-Molina, Jose A.
Buonfrate, Dora
Rodari, Paola
Gotuzzo, Eduardo
Luengo, Benilde
Luengo, Benilde
Plana, María Nieves
author Henriquez-Camacho, Cesar
author_facet Henriquez-Camacho, Cesar
Pérez-Molina, Jose A.
Buonfrate, Dora
Rodari, Paola
Gotuzzo, Eduardo
Luengo, Benilde
Plana, María Nieves
author_role author
author2 Pérez-Molina, Jose A.
Buonfrate, Dora
Rodari, Paola
Gotuzzo, Eduardo
Luengo, Benilde
Plana, María Nieves
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Facultad de Medicina
Biblioteca
dc.subject.none.fl_str_mv Strongyloides stercoralis
ivermectin
moxidectin
parasitological cure
Parasitology
Animal Science and Zoology
Infectious Diseases
SDG 3 - Good Health and Well-being
Journal Article
Systematic Review
Comparative Study
Yes
yes
topic Strongyloides stercoralis
ivermectin
moxidectin
parasitological cure
Parasitology
Animal Science and Zoology
Infectious Diseases
SDG 3 - Good Health and Well-being
Journal Article
Systematic Review
Comparative Study
Yes
yes
description The aim was to assess the efficacy of ivermectin vs moxidectin for treating Strongyloides stercoralis infection. Ovid MEDLINE, Embase and Web of Science databases were searched for studies comparing ivermectin and moxidectin from inception to February 2024. The outcomes: elimination of infection or parasitological cure, mortality and serious adverse events. We calculated odds ratios (ORs) with 95% confidence intervals (CIs) for dichotomous data. Heterogeneity was assessed using Chi2 test for statistical heterogeneity and results of the I2 statistic. Two trials met the inclusion criteria that included 821 adult participants. Both studies were conducted in southeast Asia (Cambodia and Laos). Neither trial included immunocompromised patients. The mean age of the participants ranged from 40 to 45 years old, with a similar distribution of males and females. For all participants, S. stercoralis infection was confirmed by Baermann method. The evidence was moderate for parasitological cure rate. Certainty was downgraded by 1 level because of imprecision. Moxidectin was not inferior to ivermectin: OR 0.67, 95% CI 0.36-1.25 (P = 0.21), I2 = 0%, 821 participants. No deaths were reported in either trial. One trial reported mild adverse events. In total, 153/726 (21%) participants had an adverse event. The most reported symptoms were abdominal pain and headache. There is evidence for moderate quality that moxidectin is non-inferior to, and as safe as ivermectin; however, more high-quality and well-designed trials are needed. For patients with some underlying immunosuppressive disorder, or in patients who are very young or very old, current data are insufficient to be recommended.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-11-01
2024
2024-11-01
dc.type.none.fl_str_mv review article
http://purl.org/coar/resource_type/c_dcae04bc
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10641/6341
url https://hdl.handle.net/10641/6341
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
instname:Universidad de Málaga
instname_str Universidad de Málaga
reponame_str DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
collection DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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