Enantioselective Copper-Catalyzed Synthesis of Trifluoromethyl-Cyclopropylboronates
A copper-catalyzed enantioselective cyclopropanation involving trifluorodiazoethane in the presence of alkenyl boronates has been developed. This transformation enables the preparation of 2-substituted-3-(trifluoromethyl)cyclopropylboronates with high levels of stereocontrol. The products are valuab...
| Authors: | , , , |
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| Format: | article |
| Publication Date: | 2021 |
| Country: | España |
| Institution: | Universidad de Alcalá (UAH) |
| Repository: | e_Buah Biblioteca Digital Universidad de Alcalá |
| Language: | English |
| OAI Identifier: | oai:ebuah.uah.es:10017/49328 |
| Online Access: | http://hdl.handle.net/10017/49328 https://dx.doi.org/10.1021/acs.orglett.1c02420 |
| Access Level: | Open access |
| Keyword: | (Trifluoromethyl)cyclopropylboronates Enantioselective cyclopropanation Trifluorodiazoethane Alkenyl boronates Copper catalysis Trifluoromethylcyclopropanes Química Chemistry |
| Summary: | A copper-catalyzed enantioselective cyclopropanation involving trifluorodiazoethane in the presence of alkenyl boronates has been developed. This transformation enables the preparation of 2-substituted-3-(trifluoromethyl)cyclopropylboronates with high levels of stereocontrol. The products are valuable synthetic intermediates by transformation of the boronate group. This methodology can be applied to the synthesis of novel trifluoromethylated analogues of trans-2-arylcyclopropylamines, which are prevalent motifs in biologically active compounds. |
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