Effects of a sodium-free salting agent on blood hepatic, renal and cardiac biochemical markers of normal and hypertensive rats

Introduction: Hypertension is one of the risk factors for cardiovascular diseases, being directly associated with high consumption of sodium. Objective: To assess the levels of hepatic, renal and cardiac injury markers in hypertensive rats compared to their normotensive controls, treated with a salt...

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Bibliographic Details
Authors: Menezes-Rodrigues, Francisco Sandro, Ferraz, Renato Ribeiro Nogueira, Oliveira, Alex Sandro Felisberto, Silva, Marcos José da, Bergantin, Leandro Bueno, Ambrósio, Ricardo Thiago Paniza, Fantoni, Alessandra de Oliveira, de Paula, Luciana, Errante, Paolo Ruggero, Serinolli, Mário Ivo, Caricati-Neto, Afonso
Format: article
Status:Published version
Publication Date:2017
Country:Brasil
Institution:Universidade Nove de Julho (UNINOVE)
Repository:Revista Conscientiae Saúde (Online)
Language:Portuguese
OAI Identifier:oai:ojs.periodicos.uninove.br:article/7118
Online Access:https://periodicos.uninove.br/saude/article/view/7118
Access Level:Open access
Keyword:Hypertension
Cardiac frequency
Nutraceutical
NaCl.
Hipertensão
Frequência cardíaca
Nutracêuticos
Description
Summary:Introduction: Hypertension is one of the risk factors for cardiovascular diseases, being directly associated with high consumption of sodium. Objective: To assess the levels of hepatic, renal and cardiac injury markers in hypertensive rats compared to their normotensive controls, treated with a salt free saline solution, water or NaCl. Methods: Hypertensive rats (SHR) and their normotensive controls (NWR) were divided into 3 groups (n = 7): G1 (water); G2 (aqueous solution containing NaCl 70 mg / kg / day); G3 (sodium salt-free aqueous solution 70 mg / kg / day). After 30 days, the animals’ blood was processed. Results: There was no difference between serum levels of total creatine kinase, creatine kinase-MB, lactate dehydrogenase, uric acid, aspartate aminotransferase and alkaline phosphatase in both NWR and SHR1 treated NaCl or Salgante. There was a decrease in creatinine in NWR and SHR treated with NaCl and Salgante comparing to controls (p <0.005). Conclusions: Daily supplementation with sodium salt-free aqueous solution and NaCl decreases serum creatinine levels in NWR and SHR groups. However, there was no change in serum levels of cardiac and hepatic injury markers.

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