Síntese, caracterização e estudo interativo com DNA de meso-tetra(1-naftil)porfirinas e seus complexos
This study aimed to synthesize meso-tetra(1-naphthyl)porphyrin and its metalloporphyrin derivatives with metals of the first transition series (ZnII, CuII, NiII, CoIII, MnIII). The compounds were characterized by elemental analysis, mass spectrometry, 1H e 13C nuclear magnetic resonance, electron sp...
| Autor: | |
|---|---|
| Tipo de recurso: | tesis de maestría |
| Estado: | Versión publicada |
| Fecha de publicación: | 2018 |
| País: | Brasil |
| Institución: | Universidade Federal de Santa Maria (UFSM) |
| Repositorio: | Manancial - Repositório Digital da UFSM |
| Idioma: | portugués |
| OAI Identifier: | oai:repositorio.ufsm.br:1/15925 |
| Acceso en línea: | http://repositorio.ufsm.br/handle/1/15925 |
| Access Level: | acceso abierto |
| Palabra clave: | Porfirina Metaloporfirina DNA Porphyrins Metalloporphyrins CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
| Sumario: | This study aimed to synthesize meso-tetra(1-naphthyl)porphyrin and its metalloporphyrin derivatives with metals of the first transition series (ZnII, CuII, NiII, CoIII, MnIII). The compounds were characterized by elemental analysis, mass spectrometry, 1H e 13C nuclear magnetic resonance, electron spectroscopy in ultraviolet- visible and infrared regions, fluorescence emission spectroscopy and cyclic voltammetry. In addition, studies of porphyrin aggregation in solution, photostability, singlet oxygen generation and theoretical calculations by DFT were also evaluated. The interaction of the porphyrin compounds with the ct-DNA were evaluated for experimentally (via UV-vis and emission spectroscopy) and through molecular docking. In both, the ability of the derivatives to establish interactions was observed, with the main binding forces being the Van der Waals interactions and hydrophobic interactions. In addition, the previous photodynamic activity of these compounds against microorganisms was also evaluated. |
|---|