Clinical review : hypertonic saline resuscitation in sepsis
The present review discusses the hemodynamic effects of hypertonic saline in experimental shock and in patients with sepsis. We comment on the mechanisms of action of hypertonic saline, calling upon data in hemorrhagic and septic shock. Specific actions of hypertonic saline in severe sepsis and sept...
| Autores: | , , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2002 |
| País: | Brasil |
| Recursos: | Universidade Federal do Rio Grande do Sul (UFRGS) |
| Repositório: | Repositório Institucional da UFRGS |
| Idioma: | inglês |
| OAI Identifier: | oai:www.lume.ufrgs.br:10183/24136 |
| Acesso em linha: | http://hdl.handle.net/10183/24136 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Choque hemorrágico Choque séptico Solução salina hipertônica Inflamação Hemorrhagic Hypertonic saline Inflammation Sepsis Shock |
| Resumo: | The present review discusses the hemodynamic effects of hypertonic saline in experimental shock and in patients with sepsis. We comment on the mechanisms of action of hypertonic saline, calling upon data in hemorrhagic and septic shock. Specific actions of hypertonic saline in severe sepsis and septic shock are highlighted. Data are available that support potential benefits of hypertonic saline infusion in various aspects of the pathophysiology of sepsis, including tissue hypoperfusion, decreased oxygen consumption, endothelial dysfunction, cardiac depression, and the presence of a broad array of proinflammatory cytokines and various oxidant species. The goal of research in this field is to identify reliable therapies to prevent ischemia and inflammation, and to reduce mortality. |
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