Profiling the Cymbopogon nardus Ethanol Extract and Its Antifungal Potential against Candida Species with Different Patterns of Resistance

The essential oil of Cymbopogon nardus, citronella, has been extensively studied. However, the chemical and biological properties of the ethanolic extract (EE) of C. nardus have not been evaluated. The aim of this study was to characterize the chemical composition of the EE of C. nardus and its acti...

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Detalles Bibliográficos
Autores: de Toledo, Luciani G. [UNESP], Ramos, Matheus A.S. [UNESP], Spósito, Larissa [UNESP], Castilho, Elza M. [UNESP], Pavan, Fernando R. [UNESP], Lopes, Érica O. [UNESP], da Silva, Isabel C. [UNESP], Zocolo, Guilherme J. [UNESP], Ribeiro, Paulo R.V., Oda, Fernando B. [UNESP], Pereira, Juhan A.S. [UNESP], dos Santos, André G. [UNESP], Bauab, Taís M. [UNESP], de Almeida, Margarete T.G.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:Brasil
Institución:Universidade Estadual Paulista (UNESP)
Repositorio:Repositório Institucional da UNESP
Idioma:inglés
OAI Identifier:oai:repositorio.unesp.br:11449/206609
Acceso en línea:http://dx.doi.org/10.21577/0103-5053.20200093
http://hdl.handle.net/11449/206609
Access Level:acceso abierto
Palabra clave:Antifungal activity
Candida spp
Cymbopogon nardus
Ethanol extract
Flavones
Phenylpropanoids
Descripción
Sumario:The essential oil of Cymbopogon nardus, citronella, has been extensively studied. However, the chemical and biological properties of the ethanolic extract (EE) of C. nardus have not been evaluated. The aim of this study was to characterize the chemical composition of the EE of C. nardus and its active fraction (FrD). Moreover, the cytotoxic and antifungal properties of these extracts against Candida species with different resistance profiles to conventional drugs were evaluated. The compounds identified in EE were mono-C- and di-C-glycosyl flavones and phenylpropanoid glycosides. Phenylpropanoid glycosides were identified in FrD. EE showed antifungal activity, with minimum inhibitory concentration (MIC) values ranging from 62.5 to 500 µg mL-1. FrD was more effective against C. glabrata, as evidenced by the lowest MIC value (15.6 µg mL-1). EE inhibited yeast growth similar to amphotericin-B, as demonstrated by similar time-kill curves. EE inhibited C. albicans hyphae formation and mature biofilm of C. albicans, C. krusei and C. parapsilosis. The results of the chemical and biological analyses of EE and its fractions provided novel information and may contribute to control of infections caused by Candida species.

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